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AACR 2024: Insilico Medicine to Present Preclinical Data for AI-Generated Cancer Drugs

AACR 2024: Insilico Medicine to Present Preclinical Data for AI-Generated Cancer Drugs
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Scientists uncover mutations that make cancer resistant to therapies targeting KRAS


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BOSTON - A gene called KRAS is one of the most commonly mutated genes in all human cancers, and targeted drugs that inhibit the protein expressed by mutated KRAS have shown promising results in clinical trials, with potential approvals by the U.S. Food and Drug Administration anticipated later this year. Unfortunately, cancer cells often develop additional mutations that make them resistant to such targeted drugs, resulting in disease relapse. Now researchers led by a team at Massachusetts General Hospital (MGH) have identified the first resistance mechanisms that may occur to these drugs and identified strategies to overcome them. The findings are published in ....

United States , Mustafa Sakhi , Samuel Klempner , Mohammed Syed , Giulia Siravegna , Aaron Hata , Meagan Ryan , Jochen Lennerz , Chendi Li , Junbing Zhang , Alexa Michel , Bryan Corcoran , Leslie Kiedrowski , Jessicaj Lin , Noritaka Tanaka , Dejan Juric , Justin Gainor , Islam Baiev , Cancer Research , Termeer Center , Mark Foundation For Cancer Research , Drug Administration , Gastrointestinal Cancer Center Program , American Cancer Society , Massachusetts General Hospital , Thoracic Cancers ,

With biotech funding at 'all-time high,' Scorpion scoops up $162 million


With biotech funding at ‘all-time high,’ Scorpion scoops up $162 million
By Anissa Gardizy Globe Staff,Updated January 7, 2021, 7:00 a.m.
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Just over two months after announcing its debut with $108 million in funding, Boston startup
Scorpion Therapeutics said Thursday it has raised an even larger amount of venture capital.
Scorpion, which focuses on “precision medicine” for cancer, said it has completed a $162 million funding round, bringing the biotech’s total venture haul to about $270 million. It’s a large amount for a new company that so far has kept much of its work under wraps, and a sign that the region’s early-stage biotech industry is vibrant, despite the pandemic. ....

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