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‘Junk DNA’ plays a key role in regulating circadian clocks January 7, 2021USC Study suggests the impact of non-coding microRNAs on circadian rhythms is tissue specific and may reveal new insights into disease processes. If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes. ....
Date Time ‘Junk DNA’ plays a key role in regulating our circadian clocks If you’ve ever had a bad case of jet lag, you know how a disruption to your body’s circadian rhythm makes it difficult to function. Molecular circadian “clocks” exist in cells throughout the body, governing more than just sleep and wake cycles they are crucial to many aspects of human health. For more than a decade, researchers have been trying to figure out what makes them tick, in search of new insights into diseases like Alzheimer’s, cancer and diabetes. Until now, that research has focused on what is known as clock genes, which encode proteins that drive oscillating cycles of gene expression affecting physiology and behavior. But research just published in the Proceedings of the National Academy of Sciences reveals the discovery of a new cog in the circadian clock a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs). ....
MicroRNAs Modulating Diurnal Rhythms in Cells Identified in Genome-Wide Study January 6, 2021 A new cell-based, genome-wide study has identified a cluster of micro RNAs (miRNAs) noncoding RNA molecules about 22 nucleotides long that constitute a new layer of modulation for clock genes responsible for circadian rhythms. Until now, most studies probing regulatory mechanisms of daily biological rhythms have focused on feedback loops that regulate protein-coding genes. Regulation of circadian rhythms is key, not only in understanding sleep, but also diseases such as Alzheimer’s, cancer, and diabetes. Understanding how miRNAs regulate the circadian clock in different tissues and organs could reveal new therapeutic approaches. ....