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Tracheal or windpipe cancer is a rare cancer and its cause is unclear. The most common squamous cell type of cancer has been linked to smoking. The main forms of treatment include surgery and radiotherapy. ....
Kruppel-like factor 2 may be a major determinant of acute respiratory distress syndrome in COVID-19 patients A study conducted at the University of Chicago, USA, has recently revealed that downregulation of an endothelial transcription factor, Kruppel-like factor 2, by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for acute respiratory distress syndrome (ARDS) frequently observed in coronavirus disease 2019 (COVID-19) patients. The study is currently available on the bioRxiv preprint server. Background ARDS characterized by pulmonary endothelial dysfunction is one of the major complications observed in hospitalized COVID-19 patients. Lung inflammation caused by viral infections is known to downregulate Kruppel-like factor 2, which is a transcription factor required for maintaining endothelial integrity. In experimental models of ARDS, a significantly downregulated Kruppel-like factor 2 expression has been found to associate with pulm ....