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Cenerimod's Development Targets Severe SLE Disease Activity

Novel S1P1 receptor modulator cenerimod shows impact on disease activity in lupus, with more pronounced benefits in those with more severe disease. ....

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Neoadjuvant Immunochemotherapy Promising in Oral SCC

A small trial reported a 60% response rate to neoadjuvant immunochemotherapy in oral squamous cell carcinoma. The study was published as a preprint and has not yet been peer reviewed. ....

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FDA Approves First-Ever Agent to Delay Type 1 Diabetes Onset

Teplizumab delayed progression to clinical type 1 diabetes by about 2 years compared with placebo in individuals destined to develop the condition because of autoantibody levels. ....

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Exploring hematological alterations in COVID-19 patients

New study findings indicated that some hematological alterations that occur during COVID-19-related hospital admission were associated with an increase in the risk of COVID-19-associated ICU admission and mortality. ....

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Drug to Delay T1D Gets Tepid Endorsement by FDA Advisors

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Teplizumab got a reticent thumbs-up from FDA advisors for an indication in delaying progression of at-risk patients to clinical type 1 diabetes (T1D).
The agency s Endocrinologic and Metabolic Drugs Advisory Committee on Thursday voted 10-7 that sufficient evidence of benefit outweighed the risks for this novel biologic.
However, a number on both sides indicated how narrowly they had come to making the opposite decision.
I voted yes but had my finger over the no button for a long time, said Jack Yanovski, MD, PhD, chief of the Section on Growth and Obesity at the National Institute of Child Health and Human Development in Bethesda, Maryland. ....

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