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MONALEESA-2 Subgroup Analysis Highlights Survival Benefit With Ribociclib/Letrozole in HR+ Breast Cancer

The frontline combination of ribociclib and letrozole significantly prolonged overall survival over letrozole alone in a subset of patients with hormone receptor–positive, HER2-negative advanced breast cancer who had de novo metastatic disease or late recurrence from neoadjuvant therapy, according to data from an exploratory analysis of the phase 3 MONALEESA-2 trial. ....

United States , Baylor University , Pierre Fabre , Daiichi Sankyo , Joyce Oshaughnessy , Esmo Breast Cancer Annual Congress , Us Oncology Research Network , Breast Cancer Annual Congress , Gilead Sciences , Baylor University Medical Center , Bristol Myers Squibb , Cancer Annual Congress , Joyceo Shaughnessy , Research Network , Ipsen Biopharmaceuticals , Odonate Therapeutics , Seattle Genetics , Carrick Therapeutics , Esmo Breast Cancer Virtual Meeting , Breast Cancer , Monaleesa 2 ,

Neoadjuvant Atezolizumab/Epirubicin Plus Trastuzumab/Pertuzumab Shows High pCR Rate in Early HER2+ Breast Cancer

Preoperative treatment with atezolizumab, epirubicin, trastuzumab, and pertuzumab led to improved rates of pathologic complete response and decreased residual cancer burden compared with trastuzumab, pertuzumab, and chemotherapy alone in patients with early-stage HER2-positive breast cancer, according to findings from the randomized phase 2 ATHENE trial. ....

Gabriel Rinnerthaler , Department Of Internal Medicine , Breast Annual Congress , University Hospital Salzburg , Annual Congress , Internal Medicine , Esmo Breast Cancer Virtual Meeting , Breast Cancer , Monaleesa 2 ,

Dr Kalinsky on Differences in Efficacy Between CDK4/6 Inhibitors in HR+/HER2- Breast Cancer

Kevin Kalinsky, MD, MS, discusses differences in efficacy data for CDK4/6 inhibitors in the treatment of patients with metastatic hormone receptor–positive/HER2-negative breast cancer. ....

Kevin Kalinsky , Department Of Hematology , Breast Cancer Research , Winship Cancer Institute Of Emory University , Glenn Family Breast Center , Emory University School Of Medicine , Medical Oncology , Emory University School , Breast Medical Oncology , Rand Glenn Family Chair , Winship Cancer Institute , Emory University , Hr Positive , Her2 Negative Breast Cancer , Cdk4 6 Inhibitors , Paloma 2 ,