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How microglia contribute to Alzheimer's disease | MIT News | Massachusetts Institute of Technology

A new study from MIT shows how a type of cells called microglia contribute to the slowdown of neuron activity seen in Alzheimer’s disease. The study found that microglia that express the APOE4 gene, one of the strongest genetic risk factors for Alzheimer’s disease, cannot metabolize lipids normally, leading to a buildup of excess lipids that interferes with nearby neurons’ ability to communicate with each other. ....

Susan Patricof , David Emmes , Josephp Disabato , Matheus Victor , Lestera Gimpelson , Nancye Sakamoto , Li Huei Tsai , Cure Alzheimer Fund , Ludwig Family Foundation , Halis Family Foundation , National Institutes Of Health , Reneee Belfer Family Foundation , Picower Institute For , Cell Stem , National Institutes , Howard Hughes Medical Institute Hanna , Postdoctoral Fellowship , Family Foundation , Cure Alzheimer , Microglia Alzheimers , Euron Lipid Metabolism , Li Huei Tsai , Matheus Victor ,