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Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness

Overexpression of Nfe2l1 increases proteasome activity and delays vision loss in a preclinical model of human blindness
science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.

United States , Cyagen Santa Clara , Leica Microsystems Gmb , Bioresource Research Center Kyoto , Biotechnology Research , Uf Interdisciplinary Center , Jackson Laboratory , Committee Of The University Florida , Resource Research Center , Santa Clara , Institutional Animal Care , Use Committee , Halt Protease , Thermo Fisher Scientific , Life Sensors , Protein Assay Reagent , Laemmli Buffer , Bio Rad Laboratories , Odyssey Infrared Imaging System , Chemidoc Imaging System , Cytoplasmic Extraction Reagents , Lysis Buffer , Microsoft Excel , Advanced Cell Diagnostics , Leica Bond , Leica Microsystems Gmbh ,

Analyzing regulatory and effector T cells in tumors

In this interview, Cerba Research describes how its teams were able to detect resident memory T cells in solid tumors thanks to multiplex immunofluorescence. ....

Louis Castel , Cerba Researchmar , Histalim Histoprofile , Akoya Biosciences , Polaristm Akoya Biosciences , Cerba Research , Sponsored Content , Patient Derived Xenograft , Leica Bond , Image Credit ,

Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML) | Journal of Translational Medicine

The survival rate for patients with relapsed and refractory acute myeloid leukaemia (R/R-AML) remains poor, and treatment is challenging. Chimeric antigen receptor T cells (CAR-T cells) have been widely used for haematologic malignancies. Current CAR-T therapies for acute myeloid leukaemia mostly target myeloid-lineage antigens, such as CD123 and CD33, which may be associated with potential haematopoietic toxicity. As a lineage-specific receptor, CD7 is expressed in acute myeloid leukaemia cells and T cells but is not expressed in myeloid cells. Therefore, the use of CD7 CAR-T cells for R/R-AML needs to be further explored. In this report, immunohistochemistry and flow cytometry were used to analyse CD7 expression in clinical samples from R/R-AML patients and healthy donors (HDs). We designed naturally selected CD7 CAR-T cells to analyse various functions and in vitro antileukaemic efficacy based on flow cytometry, and xenograft models were used to validate in vivo tumour dynamics. We ....

United States , Miltenyi Biotec , Texmacs Miltenyi Biotec , Dynabeads Gibco , Macsquant Miltenyi Biotec , Legendplex Multianalyte , Immunostainer Leica , Leica Microsystems , Beckman Navios , Second Hospital Of Hebei Medical University , Department Of Haematology , Animal Center , Hebei Medical University , Beckman Coulter , Fourth Hospital Of Hebei Medical University , Biotechnology Co , Department Of Hematology , Second Hospital , Hebei Medical , Leica Bond , Fourth Hospital , Animal Ethics Committee ,

Hematopoietic Stem Cell Transplant-Membranous Nephropathy Is Associated with Protocadherin FAT1

Significance Statement
Hematopoietic stem cell transplant (HSCT) is a treatment for certain hemat ....

United States , Bristol Myer Squibb , Jamie Altamirano Alonso , Amber Hummel , Questcor Mallinckrodt , Mark Haas Cedars , M Casal Moura , Van Keulen , Megan Maxwell , Mh Cedar Sinai Medical Center , Mayo Foundation For Education , Boehringer Ingelheim , Renal Pathology Laboratory , Department Of Laboratory Medicine , Pathology Research Core , Pathology Research Core Mayo Clinic , Amyloidosis Research Consortium , Mayo Clinic Cancer Center , Kidney International , Alexion Pharmaceuticals , Sinai Medical Center , Proteome Software Inc , Immunology Department , Shire Viropharma Inc , Mayo Clinic , Cedar Sinai ,