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Functional genomics and systems biology in human neuroscience

Neuroscience research has entered a phase of key discoveries in the realm of neurogenomics owing to strong financial and intellectual support for resource building and tool development. The previous challenge of tissue heterogeneity has been met with the application of techniques that can profile individual cells at scale. Moreover, the ability to perturb genes, gene regulatory elements and neuronal activity in a cell-type-specific manner has been integrated with gene expression studies to uncover the functional underpinnings of the genome at a systems level. Although these insights have necessarily been grounded in model systems, we now have the opportunity to apply these approaches in humans and in human tissue, thanks to advances in human genetics, brain imaging and tissue collection. We acknowledge that there will probably always be limits to the extent to which we can apply the genomic tools developed in model systems to human neuroscience; however, as we describe in this Perspect ....

Le Bihan , Acta Neuropathol , Ng Development , Brain Initiative Cell Census Network , Foundational Data Initiative For Parkinson , N Accelerating Medicines Partnership , Stem Cell , Brain Initiative Cell Census , Tabula Sapiens , Nucleic Acids Res , Proteomics Bioinformatics , Cell Biol , United Kingdom Biobank , United Kingdom , Medicines Partnership , Foundational Data Initiative ,

Orlando Pride vs. Angel City FC: Final Score 1-0 as Pride Claim Huge Win On the Road

Orlando Pride vs. Angel City FC: Final Score 1-0 as Pride Claim Huge Win On the Road
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