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Antengene and Its Partners Publish Preclinical Data Demonstrating the Encouraging Activity of Selinexor in the Prevention and Treatment of SARS-CoV-2 Infections

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SHANGHAI and HONG KONG, July 25, 2021 /PRNewswire/ In June 2021, results from a preclinical study jointly conducted by Antengene, American biopharmaceutical company Karyopharm Therapeutics and University of Georgia College of Veterinary Medicine has been published in a paper titled
selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo , in
Antiviral Research (192(2021)，105-115), a leading scientific journal in the field of virology. Results from the study showed that the nuclear export protein exportin-1 (XPO1) plays a direct role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the pathogenesis of coronavirus disease 19 (COVID-19); and the selective oral inhibitor of XPO1, selinexor, has potent anti-SARS-CoV-2 activity both in vitro and in vivo. These results demonstrated selinexor as a potential therapeutic strate ....

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