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A urine test based on University of Michigan Rogel Cancer Center research could have avoided one third of unnecessary prostate cancer biopsies while failing to detect only a small number of cancers, according to a validation study that included more than 1,500 patients. The findings appear in the March issue of the
Journal of Urology.
The MyProstateScore test, which is being commercialized by LynxDX, a U-M startup company, measures levels of cancer-specific genes in a patient s urine. It is based on U-M research that discovered that half of all prostate tumors harbor a certain genetic anomaly in which the genes TMPRSS2 and ERG relocate on a chromosome and fuse together creating an on-switch for prostate cancer development. ....

United States , Nicholasw Eyrich , Rachel Botbyl , Gary Longton , Javed Siddiqui , Scotta Tomlins , Balaji Pandian , Zoey Chopra , Yashars Niknafs , Lakshmip Kunju , Toddm Morgan , Johnt Wei , Ganeshs Palapattu , Yingye Zheng , Daniele Spratt , Jeffrey Tosoian , Brucej Trock , Johns Hopkins University , National Cancer Institute Prostate , A Alfred Taubman Medical Research Institute , Early Detection Research Network , Um Precision Health Research Scholar Award , University Of Michigan Rogel Cancer Center , Fred Hutchinson Cancer Research Institute , Prostate Cancer Foundation , Career Enhancement Program ,