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High-Resolution Cellular Map of Crohn's Disease Created

The atlas is the largest study of single cells from Crohn’s patients to date, and contains the gene expression profiles of more than 700,000 cells from 71 healthy individuals and patients in varying states of inflammation. ....

United States , Lingjia Kong , Jacques Deguine , Ramnik Xavier , Broad Institute , Technology Network , Department Of Molecular Biology At Massachusetts , Immunology Program , Massachusetts General Hospital , Klarman Cell Observatory , Harvard Medical School , Integrative Biology , Molecular Biology , Microbiome Informatics ,

New Approach to Large-Scale Single-Cell Profiling Developed

A new experimental pipeline has been developed to profile more cell types from different tissues, incorporating machine learning to collate the data and assemble the cell atlas. ....

Ayellet Segr , Kristin Ardlie , Orit Rozenblatt Rosen , Aviv Regev , Eugene Drokhlyansky , Broad Institute , Broad Cancer Program , National Institutes Of Health , Harvard Medical School , Illumina Artificial Intelligence Lab , Gtex Laboratory Data Analysis , Early Development , Bristol Myers Squibb , Coordination Center , Genentech Research , Human Cell Atlas , Human Cell , Klarman Cell Observatory , Genotype Tissue Expression , National Institutes , Laboratory Data Analysis , Harvard Medical ,

Massive single-cell atlas across human tissues highlights cell types where disease genes are active

Massive single-cell atlas across human tissues highlights cell types where disease genes are active
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Ayellet Segr , Kristin Ardlie , Orit Rozenblatt Rosen , Aviv Regev , Eugene Drokhlyansky , Broad Institute , Broad Cancer Program , National Institutes Of Health , Harvard Medical School , Illumina Artificial Intelligence Lab , Gtex Laboratory Data Analysis , Early Development , Bristol Myers Squibb , Coordination Center , Genentech Research , Human Cell Atlas , Human Cell , Klarman Cell Observatory , Genotype Tissue Expression , National Institutes , Laboratory Data Analysis , Harvard Medical ,

A new form of cell death, a better approach to sequencing, a cellular map of white fat, and more

Welcome to the March 21, 2022 installment of Research Roundup , a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. ....

United States , Ralph Mazitschek , Annabel Sangree , Ruihan Tang , Danilo Bzdok Mcgill , Audrey Griffith , Sam Freesun Friedman , Roy Kishony Technion , Viktor Adalsteinsson , Gregory Gydush , Hasmik Keshishian , Erica Nguyen , Steven Carr , Evan Rosen , Patrick Ellinor , Hattie Chung , Todd Golub , Galen Ballentine , Bryan Macdonald , John Doench , Gregory Priebe , Peter Tsvetkov , Vijay Kuchroo , Innature Communications , Broad Institute , Nature Communications ,

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery. ....

Joshua Levin , Amanda Kedaigle , Martina Pigoni , Emily Henderson , Silvia Velasco , Steven Hyman , Paola Arlotta , Bruna Paulsen , Broad Institute , Regenerative Biology At Harvard University , Harvard University , Psychiatric Research , Stanley Center , Golub Family Professor , Stem Cell , Regenerative Biology , Klarman Cell Observatory , Stem Cells ,