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TALOS-AMI Supports Clopidogrel De-escalation After Earlier Ticagrelor Post-PCI


May 17, 2021
A de-escalation antiplatelet strategy of switching from the more-potent ticagrelor (Brilinta; AstraZeneca) to clopidogrel at 1 month after PCI for acute MI is superior to continuing on ticagrelor and aspirin in terms of net clinical benefit, according to the TALOS-AMI trial.
“This study was conducted only in South Korea. However, although the prevalence of the CYP2C19 loss-of-function allele is significantly higher in Koreans than in other ethnic groups, this study showed the clinical safety of switching in this population, suggesting the potential of applying this de-escalation strategy to other ethnic groups,” said Kiyuk Chang, MD, PhD (The Catholic University of Korea, Seoul, Republic of Korea), who presented the findings in a late-breaking clinical trial session yesterday at the American College of Cardiology 2021 Scientific Session. ....

New York , United States , Soult Ukpyolsi , South Korea , Ann Arbor , Republic Of Korea , Claire Duvernoy , Roxana Mehran , Kiyuk Chang , Md University Of Michigan Health System , American College Of Cardiology , Catholic University Of Korea , Catholic University , American College , Michigan Health System , Icahn School , Mount Sinai , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , தெற்கு கொரியா , ஆண்டு ஆர்பர் , குடியரசு ஆஃப் கொரியா , ரோக்ஷணா மெஹ்ரான் , அமெரிக்கன் கல்லூரி ஆஃப் இருதயவியல் , கத்தோலிக் பல்கலைக்கழகம் ஆஃப் கொரியா , கத்தோலிக் பல்கலைக்கழகம் ,