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TUCSON, Arizona The last of twenty-eight defendants charged in two sweeping investigations into the manufacture and distribution of the controlled substance commonly referred to as spice, a synthetic cannabinoid made with chemicals, was federally sentenced on December 10 in United States District Court. The twenty-eight defendants were charged and convicted of a variety of crimes including conspiracy to possess with intent to distribute a controlled substance, conspiracy to possess with intent to distribute a controlled substance analogue, conspiracy to engage in interstate travel in aid of racketeering, conspiracy to commit mail fraud, introduction of misbranded drugs into interstate commerce, and money laundering. ....