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Novel Drug Improves Survival in Advanced Brain Cancer

The novel drug BMX-001 showed improved survival in certain patients with high-grade glioma and reduced cognitive decline caused by radiation therapy. ....

Ines Batinic Haberle , Katherineb Peters , Duke University School Of Medicine , Duke University School , Preston Robert Tisch Brain Tumor Center , Clinical Trials , Brain Cancer , Phase 2 Trial ,

Dr Peters on Vorasidenib in Residual or Recurrent IDH-Mutant Glioma

Katherine B. Peters, MD, PhD, discusses findings from the phase 3 INDIGO trial of vorasidenib in patients with recurrent or residual grade 2 glioma harboring an IDH1 or IDH2 mutation. ....

Katherineb Peters , Duke Cancer Center , Indigo Trial , Patients With Recurrent Or Residual Grade 2 Glioma Harboring An Idh1 Idh2 Mutation ,

Recurrent GBM brain tumors with few mutations respond best to immunotherapy


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DURHAM, N.C. - Glioblastoma brain tumors are especially perplexing. Inevitably lethal, the tumors occasionally respond to new immunotherapies after they ve grown back, enabling up to 20% of patients to live well beyond predicted survival times.
What causes this effect has long been the pursuit of researchers hoping to harness immunotherapies to extend more lives.
New insights from a team led by Duke s Preston Robert Tisch Brain Tumor Center provide potential answers. The team found that recurring glioblastoma tumors with very few mutations are far more vulnerable to immunotherapies than similar tumors with an abundance of mutations.
The finding, appearing online Jan. 13 in the journal ....

David Ashley , Matthias Gromeier , Roelg Verhaak , Allan Friedman , Katherineb Peters , Smitak Nair , Rogere Mclendon , Darelld Bigner , Fredericks Varn , Yeqing Chen , Jamese Herndon , Michaelc Brown , Yannick Desjardins , Xiang Lin , Mustafa Khasraw , Dina Randazzo , Erics Lipp , Henry Friedman , Danip Bolognesi , Allanh Friedman , Frances Mcsherry , Johnh Sampson , Gao Zhang , Junfei Zhao , Henrys Friedman , Duke University School Of Medicine ,