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New screening platform can be used to discover more effective drugs for type 1 diabetes


New screening platform can be used to discover more effective drugs for type 1 diabetes
With nearly 2 million Americans battling type 1 diabetes, it is no surprise that clinical therapies for the disease are constantly evolving and improving. In type 1 diabetes mellitus, the body s immune system attacks and destroys insulin-producing β-cells. As a result, people living with type 1 diabetes lose insulin secretion and encounter difficulty regulating glucose levels especially after meals.
Drugs developed to proliferate β-cells often are inefficient and have off-target effects that can dysregulate other cell types and pancreatic hormone production. To address these issues, researchers at Brigham and Women s Hospital and the Broad Institute teamed up to design next-generation β-cell-targeting proliferators: zinc-binding prodrugs (ZnPD). To achieve this, the researchers engineered a new screening platform, the Disque Platform, to better represent β-cells in the lab. Utiliz ....

United States , Peter Jones , Amit Choudhary , Jeff Karp , Emily Henderson , Kisuk Yang , Brigham Department Of Anesthesiology , Broad Institute , Karp Lab , Disque Platform , Renal Medicine , Associate Member , Perioperative Pain , ஒன்றுபட்டது மாநிலங்களில் , பீட்டர் ஜோன்ஸ் , அமித் சவுத்ரி , ஜெஃப் கார்ப் , எமிலி ஹென்டர்சன் , ப்ரிகாம் துறை ஆஃப் மயக்கவியல் , பரந்த நிறுவனம் , கார்ப் ஆய்வகம் , வட்டு நடைமேடை , சிறுநீரகம் மருந்து , இணை உறுப்பினர் , பெரியோபரேட்டிவ் வலி ,