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Living donor transplantation a better and safer alternative for liver transplant patients

Demand for donor livers for transplant patients is increasing tremendously compared to supply with over 15% of waitlist patients dying after a year.Researchers have found in a new international study. ....

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Vitamin B12 and folic acid may reverse liver inflammation and fibrosis in severe NAFLD: JAMA

Scientists at Duke-NUS Medical School in Singapore have uncovered a mechanism that leads to an advanced form of fatty liver disease-and it turns out that vitamin B12 and folic acid supplements could. ....

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Air Pollution Linked to Fatty Liver Disease: Study

Accumulating animal studies have shown that breathing air pollutants may increase the risk of MAFLD. For instance, fine particulate matter exposure may trigger nonalcoholic steatohepatitis (NASH)-like phenotype, impair hepatic glucose metabolism, and promote hepatic fibrogenesis. Air Pollution Linked to Fatty Liver Disease: Study. ....

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Metacrine Announces Publication of MET409 NASH Proof-of-Concept Study Results in the Journal of Hepatology

Publication highlights the first clinical evidence that the risk-benefit profile of FXR agonists can be enhanced through structural optimizationSAN DIEGO, Feb. 16, 2021 (GLOBE NEWSWIRE) Metacrine, Inc. (Nasdaq: MTCR), a clinical-stage biopharmaceutical company focused on discovering and developing differentiated therapies for patients with liver and gastrointestinal diseases, today announced that the Journal of Hepatology has published the results from the company’s 12-week, randomized, placebo-controlled Phase 1b study of MET409, the company’s lead farnesoid X receptor (FXR) agonist, in patients with non-alcoholic steatohepatitis (NASH). “The publication of our Phase 1b study data in this highly regarded, peer-reviewed journal further underscores the promise of an optimized FXR to treat patients with NASH, a potentially life-threatening liver disease with no approved treatments,” said Hubert C. Chen, M.D., chief medical officer of Metacrine. “MET40 ....

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