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Protecting lungs from ventilator-induced injury


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COLUMBUS, Ohio - An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.
In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn t able to completely prevent ventilator-induced injury to the lungs.
The team is working on exploiting that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators. Delivering high levels of the helpful molecule with a nanoparticle was effective at fending off ventilator-related lung damage in mice on mechanical ventilation. ....

United States , Samir Ghadiali , Robert Lee , Muchun Tsai , John Christman , Qinqin Fei , Pragi Patel , Joshua Englert , Joshuaa Englert , Megan Ballinger , Rachel Putman , Hyunwook Lee , Carleen Spitzer , Emily Caldwell , Vasudha Shukla , Christopher Bobba , Nature Communications , Lung Research Institute , Department Of Defense , National Institutes Of Health , Ohio State University Wexner Medical Center , College Of Pharmacy , College Of Medicine , Ohio State , Davis Heart , Mark Wewers ,

Boosting a natural cellular process could lower ventilator-related lung damage


Boosting a natural cellular process could lower ventilator-related lung damage
An unfortunate truth about the use of mechanical ventilation to save the lives of patients in respiratory distress is that the pressure used to inflate the lungs is likely to cause further lung damage.
In a new study, scientists identified a molecule that is produced by immune cells during mechanical ventilation to try to decrease inflammation, but isn t able to completely prevent ventilator-induced injury to the lungs.
The team is working on exploiting that natural process in pursuit of a therapy that could lower the chances for lung damage in patients on ventilators. Delivering high levels of the helpful molecule with a nanoparticle was effective at fending off ventilator-related lung damage in mice on mechanical ventilation. ....

United States , Ohio State University , Joshuaa Englert , Samir Ghadiali , Emily Henderson , Nature Communications , Wexner Medical Center , Study Co Lead Author , Assistant Professor , Critical Care , Sleep Medicine , Ohio State , Immune Response , Immune System , ஒன்றுபட்டது மாநிலங்களில் , ஓஹியோ நிலை பல்கலைக்கழகம் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , வெக்ஸ்னர் மருத்துவ மையம் , படிப்பு இணை வழி நடத்து நூலாசிரியர் , உதவியாளர் ப்ரொஃபெஸர் , முக்கியமான பராமரிப்பு , தூங்கு மருந்து , ஓஹியோ நிலை , நோய் எதிர்ப்பு சக்தி பதில் , நோய் எதிர்ப்பு சக்தி அமைப்பு ,