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First Patient Dosed in Phase II 'IPAX-Linz' Study of TLX101 for Glioblastoma Therapy

MELBOURNE, Australia, Nov. 22, 2022 /PRNewswire/ Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company)today announces that a first patient has been dosed in a Phase II investigator-initiated study of TLX101 in combination with external beam radiation therapy (EBRT) in patients with recurrent high-grade gliomas (HGG), including glioblastoma multiforme (GBM). TLX101 (4-L-[131I] iodo-phenylalanine, or 131I-IPA) is one of Telix's lead therapeutic clinical programs and has been granted orphan drug designation in the U.S. and Europe. TLX101 targets L-type amino acid transporter 1 (LAT-1), typically over-expressed in many malignant tumours, including HGG/GBM. The IPAX-Linz study, which is being led by Professor Josef Pichlerat Kepler University Hospital in Linz, Austria, builds on data generated in the IPAX-1 study. The final results of the IPAX-1 study, reported in September 2022, demonstrated a favourable safety profile and encouraging preliminary therapeutic effect.[1] IPAX-Lin ....

United States , United Kingdom , Ordensklinikum Linz , Kyahn Williamson , Colin Hayward , Barmherzige Schwestern , Josef Pichler , Christian Behrenbruch , Telix Pharmaceuticals , Kepler University Hospital , Kepler University Hospital In Linz , Drug Administration , Australian Securities Exchange , Australian Therapeutic Goods Administration , Corporate Communications , Telix Pharmaceuticals Limited , Health Canada , Professor Josef Pichler , Principal Investigator , Chief Medical Officer , Managing Director , Group Chief Executive , Nov 22 , 022 Prnewswire Telix Pharmaceuticals Limited Asx Tlx , He Company Today Announces Thata First Patient Has Been Dosed Ina Phase Ii Investigator Initiated Study Of Tlx101 In Combination With External Beam Radiation Therapy Ebrt Patients Recurrent High Grade Gliomas Hgg , Ncluding Glioblastoma Multiforme Gbm Tlx101 4l 131i Iodo Phenylalanine ,