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Targeting molecular pathway that causes pulmonary arterial hypertension

Targeting molecular pathway that causes pulmonary arterial hypertension
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San Diego , United States , University Of California San Diego , Patriciaa Thistlethwaite , Yu Zhang , Moises Hernandez , Sebastian Alvarez , Xena Morataya , Nolan Winicki , Jonathan Gower , John Shyy , Uc San Diego Health , Uc San Diego School Of Medicine , Science Translational Medicine , California San Diego School , Diego School , Diego Health , Translational Medicine ,

Novel coronavirus' spike protein plays additional key role in illness


Salk Institute
LA JOLLA–(April 30, 2021) Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that they also play a key role in the disease itself.
The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level. The findings help explain COVID-19’s wide variety of seemingly unconnected complications, and could open the door for new research into more effective therapies. ....

John Shyy , University Of California San Diego , Research Professor Uri Manor , Circulation Research , Assistant Research Professor Uri Manor , California San Diego , Jiao Zhang , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா சான் டியாகோ , சுழற்சி ஆராய்ச்சி , கலிஃபோர்னியா சான் டியாகோ ,