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Last modified on Wed 3 Feb 2021 07.33 EST How does a single fertilised egg divide and morph into an embryo with head, tail, limbs and organs? That question was an inexhaustible source of fascination to the biologist Lewis Wolpert, who has died aged 91. With a twinkle in his eye, he told audiences it was not birth, marriage or death, but gastrulation – the stage in which a uniform ball of cells folds to become differentiated layers with the beginnings of a gut – that was “truly the most important time in your life”. Wolpert combined his interest in fundamental problems of development with a parallel career as a science communicator. He enjoyed performing in public, and brooked no compromise in his quest to persuade people that “science is the best way to understand the world”. He broadcast frequently on BBC radio and TV, and wrote a number of popular books. The best known of these, Malignant Sadness (1999), was a fiercely objective attempt to understand his own ....
Professor Lewis Wolpert, biologist, author and regular on TV and radio discussing science and depression – obituary After suffering suicidal depression, with his candour and dry humour Wolpert found himself in demand to talk about his experiences Professor Lewis Wolpert: a knack for explaining scientific ideas Credit: Eleanor Bentall Professor Lewis Wolpert, the developmental biologist and author, who has died of Covid-19 aged 91, was for many the approachable face of science, as a presenter or guest on numerous television and radio programmes. As a biologist Wolpert was best known for the “French flag” model of embryonic development, proposed in a landmark 1969 paper, “Positional Information and the Spatial Pattern of Cellular Differentiation”, in which he used the French tricolor as a visual aid to show how embryonic cells can interpret genetic code to create the same pattern, even when certain pieces of the embryo are removed. ....