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Frontiers | Enterovirus 71 Antagonizes Antiviral Effects of Type III Interferon and Evades the Clearance of Intestinal Intraepithelial Lymphocytes

Enterovirus 71 (EV71) is the major pathogen causing severe neurological complications, hand, foot, and mouth disease. The intestinal mucosal immune system has a complete immune response and immune regulation mechanism, consisting of densely arranged monolayer intestinal epithelial cells (IECs) and intestinal intraepithelial lymphocytes (iIELs) distributed among the IECs, which constitute the first line of intestinal mucosa against infection of foreign pathogens. As an enterovirus, EV71 is transmitted by the intestinal tract; however, the mechanisms it uses to evade the immunosurveillance of the intestinal mucosal immune system are still incompletely clarified. The present study investigated how EV71 evades from recognizing and eliminating IECs, iIELs, and iNK cells. We found that EV71 infection-induced higher level of type III interferons (IFN-λ) than type Ⅰ interferons (IFN-β) in IECs and the addition of IFN-λ markedly restricted EV71 replication in IECs. These results indicate t ....

South Korea , United States , United Kingdom , Uppsala Lan , Jianwei Wang , Hanzhong Wang , Bingqing Li , Van Kaer , Peprotech Cranbury , Pamps Peterson , National Natural Science Foundation Of China , Shandong Provincial Natural Science Foundation , Institute Of Basic Medicine , Institute Of Pathogen Microbiology , Chinese Academy Of Sciences , Treestar Inc , National Major Science Technology Project For , Chinese Academy Of Medical Sciences , Wuhan Institute Of Virology , Ge Healthcare , Beckman Coulter Inc , Wuhan Institute , Chinese Academy , Minimum Essential Modified , Beijing Four Rings Bio Pharmaceutical , Pathogen Microbiology ,

The Road from Galwan: The Future of India-China Relations


Summary
On June 15, 2020, Indian and Chinese troops engaged in a brawl that left twenty Indian soldiers dead while causing an unspecified number of Chinese casualties. The clash is a part of a broader border standoff along the Galwan River between the two forces on the Line of Actual Control that is yet to be resolved. The Indian strategic community is broadly in agreement that this border dispute marks an implacable decline in India-China ties. They argue that the very basis of relations that emerged after former Indian prime minister Rajiv Gandhi’s visit to Beijing in 1988 has been shaken, if not destroyed. Yet, how did the two countries manage to reach this nadir in ties, and furthermore, what does the Galwan clash signify for the future of Sino-Indian relations? ....

Jammu And Kashmir , United States , United Kingdom , New Delhi , South China Sea , Brunei General , Gorod Astana , San Francisco , Zhang Jie , Indian Ocean , Dong Wang , North West Frontier , Jakarta Raya , New York , University Of Washington , Republic Of , South Africa , Andaman And Nicobar Islands , Galwan River , India General , Republic Of India , Lou Chunhao , Sutirtho Patranabis , Pan Jingguo , Joe Biden , John Foster Dulles ,