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CRISPR genome-editing technology helps scientists to explore many cancer-linked mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. ....

Stefani Spranger , Nimisha Pattada , Jennifer Khirallah , Peyton Randolph , Gregory Newby , Katie Holland , Christina Cabana , Jessie Davis , Grissel Cervantes Jaramillo , Qiaobing Xu , Kim Mercer , Brendan Horton , Andrew Anzalone , David Liu , Samuel Gould , Nicolas Mathey Andrews , Emily Henderson , Zachary Kulstad , Sean Luc Shanahan , Tyler Jacks , Davidh Koch , Peter Westcott , William Rideout , Research Support Committee , Broad Institute , Howard Hughes Medical Institute Hanna Grey Fellowship ,

Gene-editing technique could speed up study of cancer mutations

In an advance that could help scientists learn more about cancer-linked mutations whose roles are not known, MIT researchers have developed a way to easily engineer specific cancer-linked mutations into mouse models, using CRISPR prime editing. ....

Peyton Randolph , Qiaobing Xu , Brendan Horton , Grissel Cervantes Jaramillo , Nicolas Mathey Andrews , Sean Luc Shanahan , Andrew Anzalone , Zachary Kulstad , David Liu , Kim Mercer , Gregory Newby , Katie Holland , Jennifer Khirallah , Tyler Jacks , Stefani Spranger , Samuel Gould , Nimisha Pattada , Jessie Davis , Christina Cabana , Peter Westcott , Davidh Koch , William Rideout , Broad Institute , National Institutes Of Health , V Foundation For Cancer Research , Lustgarten Foundation For Pancreatic Cancer Research ,