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Gene variants increase risk of Addison's disease


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Gene variants increase risk of Addison’s disease
Variants of nine genes increase the risk of developing Addison’s disease, a rare disease in which the immune system attacks the adrenal glands. That is according to the largest genetic study to date on patients with Addison’s disease. The findings help increase knowledge about what causes the disease. The study was conducted by researchers at Karolinska Institutet, Sweden, and Bergen University, Norway, and is published in the journal Nature Communications.
Daniel Eriksson, private photo.
“By studying the single largest collection of samples from patients with Addison’s disease, we’ve been able to carry out the first genetic study of the disease that spans the entire human genome,” says Daniel Eriksson, doctor and researcher in the experimental endocrinology group at the Department of Medicine, Solna, Karolinska Institutet, who has led the study with doctoral student Maribel Aranda and docent ....

Morten Knappskog , Maribel Aranda Guill , Holte Berger , Anna Lena Hulting , Marc Vaudel , Haydee Artaza Alvarez , Ileana Botusan , Olov Ekwall , Stefan Johansson , Nils Landegren , Lars Breivik , Alberto Falorni , Maribel Aranda , Karolinska Institutet , Bergithe Eikeland Oftedal , Eirik Bratland , Eysteins Husebye , Jeanette Wahlberg , Daniel Eriksson , Marianne Grytaas , Anette Susanne , Sophie Bensing , Kristian Fougner , Johan Svartberg , Ellen Christine , Norwegian Addison Registry Study Group ,