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Researchers re-create key human embryo stage in lab

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This lab-grown ball of human cells shares many similarities with 5-day-old human embryos.
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
Researchers re-create key human embryo stage in lab
Mar. 17, 2021 , 12:25 PM
A human embryo at the blastocyst stage is smaller than the tip of a ballpoint pen and may contain fewer than 100 cells, but this developmental waypoint has long puzzled and vexed biologists and physicians. Many miscarriages occur during this stage, for example, and a blastocyst can also split to create twins. Now, multiple research groups have found ways to mimic blastocysts, coaxing lab-grown human cells to form clusters that closely resemble the true thing. ....

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Janet Rossant receives the 2021 ISSCR Achievement Award

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IMAGE: Janet Rossant, PhD is a leader in mammalian developmental and stem cell biology who has made seminal contributions to our understanding of early development and pioneered innovative technologies to manipulate.
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Credit: Gairdner Foundation
Skokie, IL The International Society for Stem Cell Research (ISSCR) will award its 2021 Achievement Award to Janet Rossant, PhD, FRS, FRSC, President and Scientific Director of Gairdner Foundation, Chief of Research and Senior Scientist, Research Institute, The Hospital for Sick Children, Toronto, Canada.
The prize recognizes the transformative body of work of an investigator that has had a major impact on the field of stem cell research or regenerative medicine. Dr. Rossant will present her science on 24 June at a lecture taking place at 1:15 p.m. EDT (13:15 EDT) during ISSCR 2021 Virtual, the world s leading meeting of global innovators in stem cell science and regenerative medicine. ....

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New criteria bring stem cell research one step closer to long-sought goal

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New criteria bring stem cell research one step closer to long-sought goal
Creating stem cells that can give rise to any cell type in the early embryo and its supporting structures, including the placenta: some call it ‘the holy grail’ of stem cell research. An international team of researchers offer new criteria to determine whether a mouse stem cell line has this much-wanted ability, known as totipotency.
Fluorescent image showing labelled cells in mouse embryos and gene expression, where white is each cell of the embryo, blue cells are descendants of a single totipotent cell that was combined with an unlabelled embryo, and magenta is the SOX2 and SOX17 genes showing cells that will give rise to the embryo proper or foetus. The blue cells can be seen in both the embryonic inner part of the embryo as well as the outer extra-embryonic placental progenitor part of the embryo. Credit: Eszter Posfai and Janet Rossant. ....

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Advances in research on most general type of stem cells

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Advances in research on most general type of stem cells
Mouse embryo following injection of truly totipotent morula cells labeled in magenta. Morula cells are found shortly after an egg is fertilized. Credit: Eszter Posfai.
Stem cell research is the prerequisite for regenerative medicine, which with the help of the body’s cells recreates and heals important organs. Now, researchers at Karolinska Institutet, SickKids in Canada and KU Leuven in Belgium have found a method for defining the most general type of stem cells, that can develop into all cell types in the body. The study of totipotent stem cells in mice has been published in Nature Cell Biology. ....

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