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“These vaccines are very similar,” says Jamie K. Alan, Pharm.D., Ph.D., associate professor of pharmacology at Michigan State University. “They differ in the inactive ingredients, but the mode by which they work is nearly identical.”
Even though the Pfizer and Moderna vaccines are similar, mixing them is not recommended.
The CDC specifically says in interim guidance that the COVID-19 vaccines are “not interchangeable,” adding that, “the safety and efficacy of a mixed-product series have not been evaluated.” Instead, the agency says, both doses of the vaccine series with an mRNA vaccine should be completed with the same product.
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