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Game are changing when parents are asked the question, would you let your kids play. Nightly news begins now. Good evening. A former appointee of governor Chris Christie of new jersey says he has evidence the governor knew of the forced slowdown on the George Washington bridge between new jersey and new york while it was going on and that he is prepared to prove it. Despite the governors repeated denial, tonight this scandal has again engulfed Chris Christie, embarrassingly on the eve of the super bowl, the first ever held in new jersey. Tonight, the states leading newspaper is saying if this is true, the governor must resign, and harvard law professor Alan Dershowitz said tonight Chris Christie needs to hi ....

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Poloxamer 188 Flops for Sickle Cell Disease Pain


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Poloxamer 188 failed to shorten the duration of painful vaso-occlusive episodes in children and adults with sickle cell disease (SCD), a multicenter phase III trial showed.
In over 300 patients, the mean time from randomization to the last administration of parenteral opioids was similar with poloxamer 188 compared with placebo (81.8 vs 77.8 hours, respectively) a difference that was not statistically significant, reported James Casella, MD, of Johns Hopkins University School of Medicine in Baltimore, and colleagues.
These results, published in
JAMA, conflicted with an earlier phase III study that found a benefit with poloxamer 188 in SCD patients particularly those treated with hydroxyurea who were hospitalized with a vaso-occlusive episode. ....

Jody Zylke , James Casella , Zylkej Poloxamer , Johns Hopkins University School Of Medicine , Johns Hopkins University School , Editor Jody Zylke , ஜேம்ஸ் கேசெல்லா , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , ஜான்ஸ் ஹாப்கின்ஸ் பல்கலைக்கழகம் பள்ளி ,