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Molecular jackhammers eradicate cancer cells by vibronic-driven action

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12 J cm−2, 80 mW cm−2 for 2.5 min), resulting in complete eradication of human melanoma cells in vitro. Also, 50% tumour-free efficacy in mouse models for melanoma was achieved. The molecules that destroy cell membranes through VDA have been termed molecular jackhammers because they undergo concerted whole-molecule vib ....

Ayala Orozco , Nano Lett , J Raman Spectrosc , Quantum Electron , Yagci Acar , Raman Spectrosc ,

Fluorescence-free Raman material identification

In Raman spectroscopy, accurate and sensitive identification of chemicals and materials can be compromised by fluorescence from laser excitation of the target substance itself and/or interferents in the sample matrix. Click to read more. ....

Bruker Bravo , Metrohm Raman , Li Vigni , J Raman Spectrosc , Xtract Raman , Xtracting Raman , Fluorescence Suppression Methods , Raman Spectroscopy Of Pharmaceuticals Using Complementary Metal , Oxide Semiconductor , Fluorescence Suppression , Sequentially Shifted Excitation , Rigaku Progeny Resq , Indium Gallium Arsenide , Proprietary Smartacquire , Background Subtraction , Fluorescence Suppression Techniques , Suppressed Time Resolved Raman Spectroscopy , Single Photon Avalanche Diode , Shifted Excitation Raman Spectroscopy , Innovative Tool , Situ Chemical Interrogation , Raman Vibrational , Parmigiano Reggiano Authenticity , Handheld Raman , Foods Basel , Food Control ,

S.T.E.M Girl Power - International Day of Women in Science 2022

Friday, February 11th was International Day of Women and Girls in Science 2022 which represents S.T.E.M girl power. ....

New York , United States , Mediterranean Sea , Oceans General , Cornell University , Metropolitan Museum Of Art , Silvia Merlino , Nobuko Shibayama , Carmen Garc , Adriana Rizzo , Bw Teki Raman , Laura Ortiz Herrero , Maite Maguregui , J Raman Spectrosc , Sandra Manigand Potin , April Gu , University Institute Of Research , Department Of Analytical Chemistry , National Research Council , Police Sciences , University Of The Basque Country , Colorant In Oil , Museum Of Art , International Day Of Women , Professor Of The Department Analytical Chemistry , University Of Winnipeg ,

Enhancing Biophysics Research with Raman Spectroscopy

Raman spectroscopy has become an essential tool for chemists, physicists, and biologists. By analyzing subtle molecular vibration modes, the technique enables high-sensitivity non-invasive structural studies of different water-soluble and membrane-bound biomolecules (DNA, RNA, proteins) and their interactions under physiological conditions. ....

Forance Shutterstock , J Raman Spectrosc , Cvetelin Vasilev , Photons Reveals Molecular , Raman Imaging , Comprehensive Review , Raman Spectroscopy , Stimulated Raman Scattering Microscopy Techniques , Raman Scattering , From Structural Biology , Direct Observation , Biophysics Research ,

The Determination of Microplastics via Portable Raman Microscopy

In this article, Metrohm Middle East discusses how their portable Raman microscopy equipment can be utilized in the measurement of microplastics, which are becoming a pollutant of ever-greater concern. ....

United States , Sri Lanka , Kristen Frano , J Raman Spectrosc , Jonathanh Cohen , Taylor Hoffman , University Of Delaware School Marine Science , Regional Support Centre For Metrohm Ag Switzerland , National Oceanic , Laboratory Methods For The Analysis Of Microplastics , Atmospheric Administration , Metrohm Middle East , Image Credit , Although Fourier Transform Infrared , Portable Raman , Delaware Bay , Regional Support Centre , Policy Taylor Hoffman , Policy Kristen Frano , Delaware School , Marine Environment , Quantifying Synthetic ,