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Novartis Pharma AG: Novartis announces iptacopan met Phase II study primary endpoint in rare kidney disease IgA nephropathy (IgAN)


Novartis Pharma AG: Novartis announces iptacopan met Phase II study primary endpoint in rare kidney disease IgA nephropathy (IgAN)
3-7
C3 glomerulopathy
Basel,
2
1 - Novartis today announced Phase II primary endpoint data showing investigational iptacopan (LNP023) - a first-in-class, oral, targeted factor B inhibitor - reduced protein in the urine (proteinuria), an increasingly recognized surrogate marker correlating with progression to kidney failure
2, and showed promise in stabilizing kidney function in patients with IgA nephropathy (IgAN)
1. The data were presented at the 58
th ERA-EDTA Congress held virtually from June 5-8, 2021.
In the Phase II study (NCT03373461), patients (n=112) with IgAN were randomized to placebo or different doses of iptacopan ....

Czech Republic , United States , Isabella Zinck , Thomas Hungerbuehler , Van Praet , Jonathan Barratt , Samir Shah , Jamie Bennett , Julie Masow , Sloan Simpson , Phil Mcnamara , John Tsai , J Nephrol Renovasc , University Of Leicester , Head Of Global Drug Development , Novartis Institutes For Biomedical Research , Novartis Us External Communications , Exchange Commission , European Medicines Agency , Renal Medicine , Leicester General , Global Drug Development , Chief Medical Officer , Therapy Designation , Novartis Institutes , Biomedical Research ,

DGAP-News: Proenkephalin (penKid(R)) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients


DGAP-News: Proen .
DGAP-News: Proenkephalin (penKid(R)) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients
vom 16.12.2020, 10:00 Uhr
Bild: pixabay.com
DGAP-News: SphingoTec GmbH
/ Key word(s): Scientific publication/Statement
Proenkephalin (penKid(R)) included in the ADQI consensus statements publication as functional kidney biomarker for the management of AKI patients
16.12.2020 / 10:00
The issuer is solely responsible for the content of this announcement.
The latest consensus meeting of international experts in critical care and nephrology supports the use of novel biomarkers in the prevention and management of Acute Kidney Injury (AKI)
The consensus recommends using a combination of damage and functional biomarkers together with clinical information for routine practice ....

San Diego , United States , Andreas Bergmann , Sphingotec Gmbh , J Nephrol Renovasc , Sphingotec Gmb , Ruxandra Lenz , Peter Pickkers Radboud University , Disease Quality Initiative , Clin Chem Lab , Nexus Dx Inc , Distribution Services , Acute Kidney Injury , Acute Disease Quality Initiative , Care Unit , Peter Pickkers , Radboud University , Intj Nephrol Renovasc Dis , Acute Kidney Injury Biomarkers From , Consensus Statement , Critical Care Medicine , Early Biomarker , Septic Acute Kidney Injury , Septic Shock , Kidney Int Rep , New Biomarker ,