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Seems like the past generations, our parents generations have failed us and so now we have to take on the responsibility to make sure that we do not repeat the same mistake and to make sure that we fulfill the dream. all right. thank you so much, all of you, for coming in and i really, really appreciate it, and you know, still a lot of work to do, as you said, but it is important to commemorate such a historic and critical moment led by your father and your grandfather. thank you. yes. thank you for having us. and we ll be right back. tspo. so, no matter what, i m running this kitchen. (vo) make the switch. it s your business. it s your verizon. your paint is really bad. what? i said, “best coffee i ve ever had.” (slurps) should ve used behr. sorry, sign where? no, i said, “should ve used behr. today let s paint. right now, get america s most trusted paint brand at a new low price. behr. only at the home depot. ....
Getting in shape is the number one New Year's resolution. But 80% of people have failed their goals by February because they haven't figured out how to make fitness habits stick. ....
2Department of Health Studies, FH Joanneum University of Applied Sciences, Graz, Austria Huntington’s disease (HD) is caused by an expansion of CAG triplets in the huntingtin gene, leading to severe neuropathological changes that result in a devasting and lethal phenotype. Neurodegeneration in HD begins in the striatum and spreads to other brain regions such as cortex and hippocampus, causing motor and cognitive dysfunctions. To understand the signaling pathways involved in HD, animal models that mimic the human pathology are used. The R6/2 mouse as model of HD was already shown to present major neuropathological changes in the caudate putamen and other brain regions, but recently established biomarkers in HD patients were yet not analyzed in these mice. We therefore performed an in-depth analysis of R6/2 mice to establish new and highly translational readouts focusing on Ctip2 as biological marker for motor system-related neurons and translocator protein (TSPO) as a promisi ....