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Comparison of 3 optimized delivery strategies for completion of isoniazid-rifapentine (3HP) for tuberculosis prevention among people living with HIV in Uganda: A single-center randomized trial

Fred C. Semitala and colleagues compared three delivery strategies for the completion of Isoniazid-Rifapentine for tuberculosis prevention among people living with HIV in Uganda. ....

United States , South Africa , South African , Universitatsklinikum Heidelberg , Claudiam Denkinger , World Health Organization , Makerere University , University Of California San Francisco , Dots Everwell Health Solutions , Us National Heart , Blood Institute , Stata Corporation , National Tb Programs , Empathy Studio , Creative Commons Attribution License , Supporting Information , Diversity Innovation Hub , Saharan African , California San Francisco , Mulago Immune Suppression Syndrome , Everwell Health Solutions , Adverse Events , Antiretroviral Therapy , Decision Making , Socioeconomic Aspects Of Health ,

Evaluating pediatric tuberculosis dosing guidelines: A model-based individual data pooled analysis

Lufina Galileya and colleagues pooled data from large pharmacokinetic studies to identify key covariates influencing drug exposure to optimize tuberculosis dosing in children. ....

University Of Cape Town , Western Cape , South Africa , United Kingdom , Marie Louise Newell , Njahira Mukui , University Of Southampton , World Health Organization , Health Organization , Creative Commons Attribution License , Neglected Diseases , Medical Research Council Clinical Trials Unit , University College London , Cape Town , World Health , Performance Computing , Drug Administration , Antiretroviral Therapy , Body Weight ,

New study reveals turmeric and Tinospora Cordifolia reduce liver injury risk in TB patients

The effectiveness of herbs and alternative medicines in preventing liver injury induced by anti-tuberculosis (anti-TB) drugs. ....

Sewcreamstudio Shutterstock , Scientific Reports , N Acetyl Cysteine , Cochrane Risk , Aspartate Aminotransferase , Alanine Aminotransferase , Alkaline Phosphatase , Anti Inflammatory , Vitamin D ,

New TB treatments tackle the disease without wrecking your microbiome

Researchers in a study published in The Lancet Microbe examined how various tuberculosis treatment regimens affect the respiratory microbiome. They found that certain treatments control tuberculosis effectively while minimally impacting the diversity and health of the respiratory microbiome. ....

Volodimir Zozulinskyi Shutterstock , Lancet Microbe ,

Fighting tuberculosis: Breakthrough analysis reveals mixed strain infections

The drug-resistant genotypes in mixed strain infection (MSI) samples of Mycobacterium tuberculosis. ....

Kateryna Kon Shutterstock , World Health Organization , Scientific Reports , Gaussian Mixture , Image Credit , Southeast Asia , Western Pacific , Eastern Mediterranean , Infection Control , Whole Genome Sequencing ,