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Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer. ....

Isabelle Ray Coquard , Manuel Rodrigues , Intidhar Labidi Galy , Institut Curie , Emily Henderson , Geneva University Hospitals , Translational Research Centre In Onco , University Of Geneva , Claude Bernard University In Lyon , Department Of Medicine , Curie Institute , Department Of Oncology , Translational Research Centre , Genomics Industry Focus , National Federation , Fight Against Cancer , Claude Bernard University , Ovarian Cancer , Brca1 Gene , Clinical Trial , Precision Medicine , Prostate Cancer ,

Lynparza Presents Possibility of Cure for Some Patients With Biomarker-Defined Ovarian Cancer

Data from two Phase III studies showed at ESMO that patients with BRCA1/2 mutations and HRD are living longer with maintenance therapy with Lynparza alone and in combination with Avastin. ....

Rhode Island , United States , Isabelle Ray Coquard , Merck Lynparza , Paul Disilvestro , Genentech Avastin , Jonathan Ledermann , University Claude Bernard Lyon , European Society For Medical Oncology Congress On , University College London Cancer Institute , European Society , Medical Oncology Congress , Myriad Genetic Mychoice , University Claude Bernard , Infants Hospital ,

Maintenance PARP Inhibition Boosts OS in Two Ovarian Cancer Trials

Results from SOLO-1 and PAOLA-1 show 'clinically meaningful' long-term results with olaparib ....

Rhode Island , United States , France General , Isabelle Ray Coquard , Paul Disilvestro , Mike Bassett , Olaparib Lynparza , Jonathan Ledermann , Cancer Institute At University College London , European Society For Medical Oncology , European Society , Medical Oncology , Infants Hospital , University College London ,

AstraZeneca: LYNPARZA (olaparib) in Combination with Bevacizumab, and as a Monotherapy, Demonstrates Clinically Meaningful Survival Benefit in 1st-Line Advanced Ovarian Cancer Across Two Phase III Trials

Landmark 5-year follow-up of PAOLA-1 Phase III trial demonstrated LYNPARZA plus bevacizumab meaningfully extended survival with 65.5% of HRD-positive patients surviving 5 years vs. 48.4% treated with ....

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Lynparza in combination with bevacizumab, and as monotherapy, demonstrates clinically meaningful survival benefit

Lynparza in combination with bevacizumab, and as monotherapy, demonstrates clinically meaningful survival benefit
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