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/PRNewswire/ Imagine you re baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick. ....
/PRNewswire/ Imagine you re baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick. ....
Imbalance of Developmental Networks Leads to Congenital Heart Disease December 16, 2020 An intricate balance of a complex mesh of genes determines the difference between normal development of the heart and congenital heart disease, a new study modeling TBX5 mutations in human heart muscle cells reveals. Congenital heart disease, an umbrella term for a variety of heart defects ranging from asymptomatic structural anomalies to severe abnormalities that disrupt cardiac function, is linked to a few genetic mutations. One of the first genes implicated in congenital heart disease was TBX5, an evolutionarily conserved DNA-regulatory factor that controls the expression of scores of other genes. ....
Read Time: Over two million babies, children, and adults in the United States are living with congenital heart disease a range of birth defects affecting the heart s structure or function. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) have made inroads into understanding how a broad network of genes and proteins go awry in a subset of congenital heart diseases. We now have a better understanding of what genes are improperly deployed in some cases of congenital heart disease, says Benoit Bruneau, PhD, director of the Gladstone Institute of Cardiovascular Disease and a senior author of the new study. Eventually, this might help us get a handle on how to modulate genetic networks to prevent or treat the disease. ....
Various Genes Involved in Congenital Heart Disease by Angela Mohan on December 15, 2020 at 3:01 PM Understanding how a broad network of genes and proteins go awry in a subset of congenital heart diseases, could help prevent and treat heart defects. The insights have been provided by the team of researchers at Gladstone Institutes and UC San Francisco (UCSF). We now have a better understanding of what genes are improperly deployed in some cases of congenital heart disease, says Benoit Bruneau, PhD, director of the Gladstone Institute of Cardiovascular Disease and a senior author of the new study. Eventually, this might help us get a handle on how to modulate genetic networks to prevent or treat the disease. ....