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Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants. ....

United States , Ann Roberth Lurie , Manne Research Institute , Pediatric Research , Stanley Manne Children , Research Institute , Lurie Children , Northwestern University Feinberg School , Intestinal Disease , Growth Factor , Necrotizing Enterocolitis ,

Anti-CTLA-4 nanobodies offer promising strategy to prevent colitis in cancer immunotherapy

Microbiota-reactive T cells trigger colitis in mice harboring the microbiota of wild-caught mice following CTLA-4 blockade, according to a new study that reveals a major mechanism by which anti-CTLA-4 antibodies induce inflammatory toxicities during antitumor immune checkpoint inhibitor therapies. ....

United States , American Association For The Advancement Of Science , Ctla 4 , Intestinal Disease ,