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Results of NIH-sponsored ACTIV-3 trial published

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IMAGE: Colorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (orange), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF).
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Credit: NIAID
Preliminary results of a phase 3, randomized, placebo-controlled clinical trial testing the investigative monoclonal antibody LY-CoV555 in hospitalized COVID-19 patients were published today in the
New England Journal of Medicine. The antibody did not provide clinical benefit compared to placebo. The trial, which had been halted to new enrollment in late October following a recommendation by the independent Data and Safety Monitoring Board (DSMB), is part of the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program. The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. ....

British Columbia , United States , Annea Oplinger , James Neaton , Alan Moskowitz , Taylor Thompson , Eli Lilly , Annetine Gelijns , Rachel Ramoni , Jens Lundgren , Abcellera Biologics , Vaccine Research Center , Network Of Networks , University Of Copenhagen , Us Department Of Health , Human Services , National Institute Of Allergy , National Institutes Of Health , Cardiothoracic Surgical Trials Network , Lilly Research Laboratories , International Network Of Strategic Initiatives In Global , Us Department Of Veterans Affairs , Blood Institute , National Heart , New England Journal , Safety Monitoring Board ,

Results of ACTIV-3 trial published: Experimental monoclonal antibody not efficacious in Phase 3 trial

Results of ACTIV-3 trial published: Experimental monoclonal antibody not efficacious in Phase 3 trial
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