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Treatment effect modification due to comorbidity: Individual participant data meta-analyses of 120 randomised controlled trials

Peter Hanlon and colleagues conduct meta-analyses of individual participant data extracted from 120 randomised controlled trials to investigate whether comorbidity modifies treatment effects. ....

United States , United Kingdom , World Health Organisation Anatomic Therapeutic Classification , Research Council , College Of Medicine , Life Sciences , Association Of The British Pharmaceutical Industry , Yale University Open Data Access , University Of Glasgow , Rr Core Team , Creative Commons Attribution License , Wellcome Trust , Medical Research Council , British Pharmaceutical Industry , Bath Ankylosing Spondylitis Functional Index , Core Outcome Measures , Effectiveness Trials , Clinical Study Data Request , Renal Disease , Medical Dictionary , Regulatory Activities , Yale Open Data , United States Clinical , Yale Open Data Access , Aggregated Analysis , American College ,

First IL-17 Inhibitor Approved in Europe for HS Patients

The European Commission has approved the first interleukin-17A inhibitor for treating hidradenitis suppurativa. ....

United States , Drug Administration , European Union , Hidradenitis Suppurativa Foundation , European Commission , Hidradenitis Suppurativa , Biologic Therapy , Skin And Soft Tissue Infection , Rheumatoid Arthritis , Psoriatic Arthritis , Acne Vulgaris , Oint Inflammation , Juvenile Rheumatoid Arthritis , Ankylosing Spondylitis , Systemic Lupus Erythematosus , Lupus Nephritis , Patient Safety , Adverse Effects , Side Effects , Ankylosing Spondylitis B ,

Dupilumab Curbs Acute COPD Exacerbations

Patients treated with dupilumab for COPD also showed significant improvements in lung function at 12 and 52 weeks. ....

United States , Surya Bhatt , American Thoracic Society International Conference , University Of Alabama At Birmingham , International Conference , Boehringer Ingelheim , New England Journal , Thoracic Society International Conference , Secondary Endpoints , Presented May , Chronic Obstructive Pulmonary Disease Copd , Chronic Obstructive Pulmonary Disease , Chronic Obstructive Lung Disease , Biologic Therapy , Quality Of Life , Ealth Related Quality Of Life , Osinophil Granulocytes , Nt Ears , Upper Respiratory Infection , Washington Dc District Of Col ,

Two Biologics Evaluated for Facial, Hand, Foot Dermatitis

Lebrikizumab was efficacious in clearing and improving facial and hand dermatitis, burdensome and difficult-to-treat areas, in most patients, Dr Jenny Murase said, in reporting results at RAD 2023. ....

United States , Palo Alto , San Francisco , University Of Pennsylvania , Eric Simpson , Eli Lilly , Jennye Murase , Chiesa Fuxench , Zelma Chiesa Fuxench , Jonathani Silverberg , Palo Alto Calf Foundation Medical Group , American Academy Of Dermatology , George Washington University , Science University , Oregon Health , University Of California , European Union , Regeneron Pharmaceuticals , Drug Administration , Revolutionizing Atopic Dermatitis , Foundation Medical , New England Journal , Investigator Global Assessment , Peak Pruritus Numerical Rating Scale , Hand Eczema Questionnaire , American Academy ,

Dupilumab Benefits Shown in Phase 3 Prurigo Nodularis Trials

The results "support the involvement of type 2 cytokines in driving PN disease pathogenesis and the targeting of the IL-4/IL-13 axis as a novel therapeutic paradigm" for PN, the authors write. ....

United States , Adam Friedman , Gil Yosipovitch , University Of Miami , Regeneron Pharmaceuticals , George Washington University , Nature Medicine , Worst Itch Numeric Rating Scale , Biologic Therapy , Prurigo Nodularis , Skin Lesion , Topical Therapy ,