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Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments. ....

United States , Drug Administration , West Nile , Ibonucleic Acid , Ars Cov 2 , Zika Virus ,

A New Generation of Cytokine-Based Immunotherapy Takes Shape

Nearly 40 years after the first cytokine-based therapy was approved for the treatment of patients with hairy cell leukemia, investigators are taking a fresh look at ways to leverage these signaling proteins to enhance immunotherapies and vaccines in other cancers. ....

Taghi Khani , Sanchez Ortiz , National Cancer Institute , Cytokine Development , Merck Kga , Therapeutics Inc , Merck Kgaa , Bristol Myers Squibb , Cancer Research Institute , Influence Cell Signaling , Select Cytokines Investigated , Interferon Cytokine , Accessed March , Opin Chem , Des Devel , Transduct Target , Accessed February , Cytokine Based Immunotherapy , T Cells , Tumor Necrosis Factors ,

Self-directed autoantibodies against certain chemokines may protect against long-COVID

A recent study published in the journal Nature Immunology discovered autoantibodies against chemokines following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ....

Nature Immunology , Industry Focus , Coronavirus Disease Covid 19 , Covid 19 , Lyme Disease , Ars Cov 2 , Evere Acute Respiratory , Evere Acute Respiratory Syndrome ,

Rockefeller scientists describe the genetics of severe SARS-CoV-2 infection in children

One of the most terrifying aspects of the COVID pandemic has been its unpredictably severe impact on some children. ....

United States , Jean Laurent Casanova , Emily Henderson , Genetic Effort , North America , Latin America , Levy Family Professor , Giles Laboratory , Human Genetics , Infectious Diseases , Genomics Industry Focus , Abdominal Pain , Immune System , Kawasaki Disease , Ars Cov 2 ,

Study reveals underlying genetic cause for MIS-C complication after COVID-19 infection

New research findings have revealed an underlying genetic cause for why some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but potentially life-threatening disease. ....

Robert Silverman , Jean Laurent Casanova , Emily Henderson , Centers For Disease , Rockefeller University , Multisystem Inflammatory Syndrome , Disease Control , Cleveland Clinic Lerner Research Institute , Genomics Industry Focus , Covid 19 , Gastrointestinal Tract ,