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Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment. ....

Kateryna Kon Shutterstock , E Coli , Interferon Gamma ,

Dietary polyphenols may play a role in regulating inflammatory immune responses

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood. ....

Katsunori Endo , Emily Henderson , International Immunopharmacology , Shinshu University , Industry Focus , Amino Acid , Anti Inflammatory , Interferon Gamma ,

Why lung cancer doesn't respond well to immunotherapy | MIT News | Massachusetts Institute of Technology

MIT researchers discovered why the immune system mounts such a lackluster response to lung cancer, even after treatment with immunotherapy drugs: Bacteria naturally found in the lungs help create an environment that suppresses T-cell activation in the lymph nodes near the lungs. ....

Stefani Spranger , Maria Zagorulya , Ludwig Center , Koch Institute , Koch Institute Frontier Research , Koch Institute For Integrative Cancer Research , School Of Science Fellowship In Cancer Research , Career Development Assistant Professor , Integrative Cancer Research , Pew Stewart Scholarship , Science Fellowship , Lung Cancer , Ancer Immunotherapy , T Cells , Dendritic Cells , Lymph Nodes , Interferon Gamma , Stefani Spranger ,

NGM Bio Gives Presentation Featuring Preclinical Characterization of NGM936 at 2022 ASH Annual Meeting

NGM Bio Gives Presentation Featuring Preclinical Characterization of NGM936 at 2022 ASH Annual Meeting
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United States , New Orleans , Brian Schoelkopf , Fabiana Perna , American Society Of Hematology , Biopharmaceuticals Inc , Exchange Commission , Indiana University School Of Medicine , Ernestn Morial Convention Center , Wall Street , American Society , Annual Meeting , Convention Center , Associate Professor , Indiana University School , Alphabetical Order , Interferon Gamma , Immunoglobulin Like Transcript , Tumor Necrosis Factor , Private Securities Litigation Reform Act , United States Securities ,

Discovery offers an avenue for development of novel therapies for Chagas disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects some 8 million people worldwide. More than a third develop severe heart or digestive problems with a heightened risk of death. ....

Edecio Cunha Neto , Christophe Chevillard , Emily Henderson , Brazilian Society Of Cardiology , Paulo Medical School , Department Of Clinical Medicine , Heart Institute , World Health Organization , Marseille University , Medical School , Clinical Medicine , Aix Marseille University , Genomics Industry Focus , Brazilian Society , Chagas Disease , Interferon Gamma , Oxidative Stress ,