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<p>Scientists from Zarbio and Georgia State University have developed a groundbreaking framework called the Amyloid Degradation Toxicity Hypothesis, providing a new perspective on Alzheimer&#39;s disease (AD). The hypothesis challenges conventional theories by suggesting that beta-amyloid peptide (A&beta;) toxicity depends on its cellular uptake, not the presence of amyloid aggregates. Published in Current Alzheimer Research, the manuscript resolves two paradoxes in AD research and explains why AD diagnosis in patients is associated with high densities of non-toxic amyloid deposits but low concentrations of toxic soluble A&beta;42. The researchers validated their conclusions using the Alzheimer&#39;s Disease Neuroimaging Initiative database. The novel hypothesis offers a promising advancement in understanding and potentially treating Alzheimer&#39;s disease, including finding biomarkers for its early diagnostics.</p>

Yaroslav molkovMaria zaretskaiaDmitry zaretskyDmitry zaretsky zarbioCurrent alzheimer researchGeorgia state universityAlzheimer disease neuroimaging initiativeAmyloid degradation toxicityAmyloid degradation toxicity hypothesisIntegrative theoryLinking molecular mechanismsBeta amyloid biomarkersDisease neuroimaging initiative