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A new model can predict the evolution of antibiotic resistance in bacteria


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A team of scientists from the University of Cologne (Germany) and the University of Uppsala (Sweden) has created a model that can describe and predict the evolution of antibiotic resistance in bacteria. Resistance to antibiotics evolves through a variety of mechanisms. A central and still unresolved question is how resistance evolution affects cell growth at different drug concentrations. The new model predicts growth rates and resistance levels of common resistant bacterial mutants at different drug doses. These predictions are confirmed by empirical growth inhibition curves and genomic data from Escherichia coli populations. The study has been published in the journal ....

Fernanda Pinheiro , University Of Cologne Germany , University Of Cologne , University Of Uppsala Sweden , Institute Of Biological Physics , Nature Ecology , Biological Physics , Chemistry Physics Materials Sciences , Biomechanics Biophysics , Pharmaceutical Sciences , பெர்னாண்டா பிந்‌ஹேரொ , பல்கலைக்கழகம் ஆஃப் கொலோன் ஜெர்மனி , பல்கலைக்கழகம் ஆஃப் கொலோன் , நிறுவனம் ஆஃப் உயிரியல் இயற்பியல் , இயற்கை சூழலியல் , உயிரியல் இயற்பியல் , வேதியியல் இயற்பியல் பொருட்கள் அறிவியல் , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , மருந்து அறிவியல் ,