Imbalance in Gut Microbiome Can Lead to Depressive-Like Behaviors
December 14, 2020
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Researchers from the Institut Pasteur, Inserm, and the French National Centre for Scientific Research (CNRS) recently conducted a study “Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system” showing that an imbalance in the gut bacterial community can cause a reduction in some metabolites, resulting in depressive-like behaviors. These findings, which show that a healthy gut microbiota contributes to normal brain function, were published in
Nature Communications.
“Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model of depression, we show that UCMS mice display phenotypic alterations, which could be transferred from UCMS donors to naïve recipien
Depression is a mental disorder that affects more than 264 million people of all ages worldwide. Understanding its mechanisms is vital for the development of effective therapeutic strategies.
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