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Indivior (INDV) Announces Publication Demonstrating that OPVEE Nasal Spray Rapidly Reverses Effects of Opioid-Induced Respiratory Depression in Head-to-Head Study Against Intranasal Naloxone

Indivior (INDV) Announces Publication Demonstrating that OPVEE Nasal Spray Rapidly Reverses Effects of Opioid-Induced Respiratory Depression in Head-to-Head Study Against Intranasal Naloxone
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United statesChristian heidbrederWiley online libraryClinical pharmacologyInduced respiratory depressionHealthy volunteersIntranasal nalmefeneIntranasal naloxoneOnline libraryChief scientific officer

Indivior Announces Publication Demonstrating that OPVEE® (nalmefene) Nasal Spray Rapidly Reverses Effects of Opioid-Induced Respiratory Depression in Head-to-Head Study Against Intranasal Naloxone

/PRNewswire/ Indivior PLC (LSE/Nasdaq: INDV) today announced results from a pharmacodynamic study demonstrating that OPVEE® rapidly reverses opioid-induced.

United statesLennonh ventilatoryChristian heidbrederHealth statisticsWiley online libraryNational centerPrnewswire indiviorClinical pharmacologyInduced respiratory depressionHealthy volunteersIntranasal nalmefeneIntranasal naloxoneOnline libraryChief scientific officerRecurrent respiratoryCentral nervous system depression

Indivior Announces Publication Demonstrating that OPVEE® (nalmefene) Nasal Spray Rapidly Reverses Effects of Opioid-Induced Respiratory Depression in Head-to-Head Study Against Intranasal Naloxone

This head-to-head pharmacodynamic study in healthy volunteers examined the ability of both OPVEE and intranasal naloxone to reverse opioid-induced respiratory depression, which is the shallow and slow breathing associated with an opioid overdose In this model, OPVEE 2.7mg reversed respiratory depression to 95% of pre-opioid baseline within 5 minutes; a similar reversal following a 4 […]

United statesChristian heidbrederLennonh ventilatoryHealth statisticsNational centerWiley online libraryClinical pharmacologyInduced respiratory depressionHealthy volunteersIntranasal nalmefeneIntranasal naloxoneChief scientific officerRecurrent respiratoryCentral nervous system depressionPartial agonistsSevere opioid withdrawal