Piperlongumine, a chemical compound found in the Indian long pepper plant, is known to kill cancerous cells in many tumor types, including brain tumors, according to Penn Medicine.
Now, an international team, including researchers from the University of Pennsylvaniaâs Perelman School of Medicine, has illuminated one way in which the piperlongumine works in animal models â and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer, the university announced in a press release.
The researchers, whose findings were published this month in ACS Central Science, showed in detail how piperlongumine binds to â and hinders the activity of â a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression.
Piperlongumine, a chemical compound found in the Indian Long Pepper plant (
Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now, an international team including researchers from the Perelman School of Medicine has illuminated one way in which the piperlongumine works in animal models and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer. Indian long pepper plant
The researchers, whose findings were published this month in
ACS Central Science, showed in detail how piperlongumine binds to and hinders the activity of a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. The scientists found that piperlongumine treatment radically shrank glioblastoma tumors and extended life in two animal models of this cancer, and also selectively destroyed glioblastoma cells taken from human patients.
PHILADELPHIA: Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now an international team including researchers from the Perelman Sc
Animal study shows how chemical compound in Indian Long Pepper works against glioblastoma
Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now an international team including researchers from the Perelman School of Medicine at the University of Pennsylvania has illuminated one way in which the piperlongumine works in animal models and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer.
The researchers, whose findings were published this month in
ACS Central Science, showed in detail how piperlongumine binds to and hinders the activity of a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. The scientists found that piperlongumine treatment radically shrank glioblastoma tumors and extended life in two mouse models of this cancer, and also select
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PHILADELPHIA Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors. Now an international team including researchers from the Perelman School of Medicine at the University of Pennsylvania has illuminated one way in which the piperlongumine works in animal models and has confirmed its strong activity against glioblastoma, one of the least treatable types of brain cancer.
The researchers, whose findings were published this month in
ACS Central Science, showed in detail how piperlongumine binds to and hinders the activity of a protein called TRPV2, which is overexpressed in glioblastoma in a way that appears to drive cancer progression. The scientists found that piperlongumine treatment radically shrank glioblastoma tumors and extended life in two mouse models of this cancer, and also selectively destroyed glioblastoma cells taken from human patients.