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E-Mail IMAGE: Researchers screened a panel of drugs that are already approved for clinical use and identified two drugs that provided effective SARS-CoV-2 suppression: cepharanthine and nelfinavir view more Credit: Louis Reed on Unsplash COVID-19 continues to claim lives across the world and is infecting millions more. Although several vaccines have recently become available, making significant strides towards preventing COVID-19, what about the treatment of those who already have the infection? Vaccines aren t 100% effective, highlighting the need now more than ever for effective antiviral therapeutics. Moreover, some people can t receive vaccines due to health issues, and new variants of SARS-CoV-2, the virus that causes COVID-19, that can penetrate vaccine-conferred immunity, are being reported, indicating that we need to think beyond prevention. ....
E-Mail IMAGE: A newly developed B cell (green in middle of image) migrates from the bone marrow of the skull, where a cluster of other new B cells remain, then through the. view more Credit: Simone Brioschi The immune system is the brain s best frenemy. It protects the brain from infection and helps injured tissues heal, but it also causes autoimmune diseases and creates inflammation that drives neurodegeneration. Two new studies in mice suggest that the double-edged nature of the relationship between the immune system and the brain may come down to the origins of the immune cells that patrol the meninges, the tissues that surround the brain and spinal cord. In complementary studies published June 3 in the journal ....
Credit: Eivind Senneset Smoking in early puberty in boys may have negative consequences for their future generations of offspring, a study from the University of Bergen (UiB) shows. By continued analysis of data gathered in the large international RHINESSA, RHINE and ECRHS studies, researchers have found that the health of future generations depends on actions and decisions made by young people today. This is particularly relevant for boys in early puberty and mothers/grandmothers both pre-pregnancy and during pregnancy, the study shows. The paper Prenatal and prepubertal exposures to tobacco smoke in men may cause lower lung function in future offspring: a three-generation study using a causal modelling approach was recently published in the ....
Protein disguise could be new target for cancer immunotherapy Researchers at the Francis Crick Institute have identified a protein that helps tumours evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments. A crucial part of the immune system s response to cancer is a group of white blood cells, called CD8+ T-cells, which kill tumour cells. Before they launch their anti-tumour response, these cells must be told who to attack by another immune cell, called a dendritic cell. In their study, published in ....
Models for professional use were the most effective at retaining aerosol particles of a size equivalent to the novel coronavirus, followed by TNT masks sold in drugstores. The efficacy of fabric masks ranged from 15% to 70%. A tight fit and lack of seams enhanced protection. ....