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email article Treatment with an HIV maturation inhibitor known as GSK3640254 or the catchy name of GSK 254 for short appeared to dramatically lower viral load in a proof-of-concept phase IIa clinical trial, researchers reported. In a 7-day trial that tested multiple doses of GSK 254, viral loads were reduced by a factor of 50 with a dose of 140 mg and by a factor of 100 with a 200-mg dose, according to Christoph Spinner, MD, of Technical University of Munich, who presented the findings at the virtual Conference on Retroviruses and Opportunistic Infections (CROI). Phase III trials will test GSK 254 at doses of 100, 150, and 200 mg in once-daily dosing, Spinner said, in combination with two nucleoside reverse transcriptase inhibitors in treatment-naïve individuals. ....
email article Developing COVID-19 during a high-risk pregnancy is a bad combination for mother and child, but having HIV infection on top of that doesn t appear to make it any worse, a study in South Africa indicated. Of 100 women diagnosed with COVID-19 while receiving care from the high-risk obstetric care service at Tygerberg Hospital in Cape Town, South Africa, there were eight deaths: six among the 72 women (8%) with COVID-19, and two among the 28 women (7%) co-infected with HIV, said Liesl De Waard, MBChB, of Stellenbosch University in suburban Cape Town. Of those women who died during the study conducted during the height of the COVID-19 pandemic only two of the babies they were carrying survived, de Waard said in her oral presentation at the virtual Conference on Retroviruses and Opportunistic Infections (CROI). ....
email article Eric Feigl-Ding, an epidemiologist and health economist and an adjunct senior fellow at the Federation of American Scientists (FAS) in Washington, D.C., was recognized in the media as one of the first to alert the public to the pandemic risk of COVID-19 in January 2020, and is now part of FAS s work to stop COVID misinformation to the public. Feigl-Ding is also a co-founder of COVID ACTION GROUP (covidactiongroup.net). In the first part of this exclusive MedPage Today video, Editor-in-Chief Marty Makary, MD, MPH, of Johns Hopkins University in Baltimore, speaks to Feigl-Ding about the many hot topics in the news right now. ....