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Researchers boost potency of an HIV-1 antibody, tracing new pathways for vaccine development

 E-Mail IMAGE: Madan, a postdoctoral researcher in the DeKosky lab at the University of Kansas School of Pharmacy, headed research into potential of the vFP16.02 antibody view more  Credit: Matheus Oliveira de Souza LAWRENCE Much like coronavirus, circulating HIV-1 viruses mutate into diverse variants that pose challenges for scientists developing vaccines to protect people from HIV/AIDS. AIDS vaccine development has been a decades-long challenge partly because our immune systems have difficulty recognizing all the diverse variants of the rapidly mutating HIV virus, which is the cause of AIDS, said Brandon DeKosky, assistant professor of pharmaceutical chemistry and chemical & petroleum engineering at the University of Kansas.

Researchers boost the potency of an HIV-1 antibody, tracing new potential pathways for vaccine development

Thu, 03/11/2021 LAWRENCE Much like coronavirus, circulating HIV-1 viruses mutate into diverse variants that pose challenges for scientists developing vaccines to protect people from HIV/AIDS. “AIDS vaccine development has been a decades-long challenge partly because our immune systems have difficulty recognizing all the diverse variants of the rapidly mutating HIV virus, which is the cause of AIDS,” said Brandon DeKosky, assistant professor of pharmaceutical chemistry and chemical & petroleum engineering at the University of Kansas. In the past five years, tremendous progress has been made in identifying better vaccine methods to protect against many different HIV-1 variants. One important step was when scientists at the National Institute of Allergy and Infectious Disease’s Vaccine Research Center discovered a promising antibody called vFP16.02. Antibodies are proteins the immune system deploys to target and destroy pathogens and viruses and scientists at the NIH determ

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