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First-of-Its-Kind Atlas Maps Complexities of Autoimmune Disease

Each person only has one genome, but different parts of the genome are active in different cell types. In the example above, a region of regulatory DNA (blue star) is active only in Cell A. This regulatory DNA controls expression level of Gene Y. Different people have different variations of that regulatory DNA sequence (AA, AG or GG genetic polymorphisms), which lead to different expression levels of Gene Y (top right red graph). This type of data was used to build the ImmuNexUT database, which will allow experts to understand how DNA sequence differences lead to changes in gene expression and cause different immune system diseases. Credit: Diagram by Mineto Ota, Creative Commons By Attribution 4.0 ....

University Of Tokyo Immunex , Chugai Pharmaceutical Co Ltd , Tokyo Project Research Associate Mineto Ota , Immune Cell Gene Expression Atlas , East Asian , கிழக்கு ஆசிய ,

Resource Links Gene Variants with Immune System Regulation and Immune-Mediated Diseases

Resource Links Gene Variants with Immune System Regulation and Immune-Mediated Diseases
April 30, 2021
University of Tokyo researchers and colleagues at the RIKEN Research Institute have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. It’s hoped that the resource will offer up new insights into how immune disorders develop, and potentially aid in drug discovery. Scientists also hope that the atlas of immune-related genome data may eventually be applied to investigations of infectious diseases, such as COVID-19.
“To understand diseases, a deep comprehension of the function of genetic variants is essential,” said University of Tokyo project research associate Mineto Ota, MD, PhD, a clinical rheumatologist and expert in functional genomics. “With this data set, we can connect the data about changes to DNA sequence associated with a disease to genes and cell types that are important for disease pathogenesis.” Ota is lea ....

Mineto Ota , University Of Tokyo Immunex , Research Institute , University Of Tokyo , Immune Cell Gene Expression Atlas , East Asian , ஆராய்ச்சி நிறுவனம் , பல்கலைக்கழகம் ஆஃப் டோக்கியோ , கிழக்கு ஆசிய ,

New atlas of genetic function maps complexities of immune system and immune diseases

Researchers in Japan have compiled a first-of-its-kind genetic database for autoimmune and autoinflammatory diseases. This resource will allow experts to. ....

Mineto Ota , University Of Tokyo Immunex , Chugai Pharmaceutical Co Ltd , Tokyo Project Research Associate Mineto Ota , Immune Cell Gene Expression Atlas , East Asian , University Of Tokyo , Rheumatoid Arthritis , Infectious Diseases , Immune Cells , கிழக்கு ஆசிய , பல்கலைக்கழகம் ஆஃப் டோக்கியோ ,

New atlas of genetic function maps complexities of immune system and immune diseases

New atlas of genetic function maps complexities of immune system and immune diseases
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Bunkyo Ku , Japan General , Caitlin Devor , University Of Tokyo Immunex , Chugai Pharmaceutical Co Ltd , School Of Medicine , Research Associate Mineto Ota , Research Publication , Division For Strategic Public Relations , Department Of Functional Genomics , Research Contact , University Of Tokyo , Tokyo Project Research Associate Mineto Ota , Immune Cell Gene Expression Atlas , East Asian , Cell Gene Expression Atlas , Functional Genomics , Immunological Diseases , Graduate School , Officer Contact , Strategic Public Relations , புங்கயோ கு , கெய்ட்லின் டேவோர் , பள்ளி ஆஃப் மருந்து , ஆராய்ச்சி வெளியீடு , பிரிவு க்கு மூலோபாய பொது உறவுகள் ,