The Book of Kells (c. 800) is an illuminated manuscript of the four gospels of the Christian New Testament, currently housed at Trinity College, Dublin, Ireland.
Recently a group of us went into our manuscripts store to have a look at some medieval genealogical rolls. We were examining Royal MS 14 B V, an English roll from the last part of the 13th century that contains quite a lot of marginalia, when one of our post-medieval.