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Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial

Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial
thelancet.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelancet.com Daily Mail and Mail on Sunday newspapers.

United kingdomJ clin hypertensClin pharmacokinetNephrol hypertensDial transplantPractice guidelineDiabetes managementChronic kidney diseaseChronic kidney disClin hypertensHypertens repOpin nephrol hypertensInt repDiabetes endocrinolEnglj med

SYMPLICITY HTN-3: failure at 6 months, success at 3 years?

In The Lancet, Deepak L Bhatt and colleagues report long-term outcomes of renal artery denervation in patients denervated by single-electrode radiofrequency within the SYMPLICITY HTN-3 study.1 This large sham-controlled trial recruited 535 patients (210 [39%] women and 325 [61%] men; mean age in renal denervation group 57·9 years [SD 10·4]) with treatment-resistant hypertension enrolled in 88 centres in the USA. The trial was expected to provide definitive evidence of the efficacy of renal denervation in patients with treatment-resistant hypertension but did not meet its primary 6-month efficacy endpoint,2 raising an unprecedented wave of scepticism about renal denervation.

United statesDeepakl bhattFadl elmulaThe lancetHypertens rep

Arterial hypertension

Arterial hypertension
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United statesSri lankaUnited kingdomJapan generalCity ofJammu and kashmirSouth koreaNat genetColl cardiolMaurerg serruysWright jrJ clin hypertensEuropean society of hypertensionAmerican heart associationWorld health assemblyHealth promotion series