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Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease

The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because of their electrophilic nature, resulting in nonspecific reactions with active cysteine residues in a variety of cellular proteins. We show that genetic and pharmacologic inhibition of the Nrf2 repressor Bach1 in a posttreatment regimen of experimental PD is neuroprotective by up-regulating Bach1-targeted pathways involving both Nrf2-dependent antioxidant response element (ARE) and non-ARE genes. Inhibition of Bach1 by a nonelectrophilic substituted benzimidazole is a promising therapeutic approach for PD. ....

United States , Johns Hopkins University , Tissue Bank , University Of Maryland Brain , University Of Maryland , Department Of Pharmaceutical Sciences , International Institute For Nanotechnology , Terrance Kavanagh University Of Washington , University Of Buffalo , Parkinson Foundation , Russian Scientific Foundation Grant No , Wenbo Zhi Augusta University , Research Center At Northwestern University , Roland Wolf University Of Dundee , Michaelj Fox Foundation For Parkinson , Curt Freed University Of Colorado , Canonical Nrf , Maryland Brain , Gene Expression Omnibus , Russian Scientific Foundation Grant , Higher School , Economics University Basic Research , Integrated Molecular Structure Education , Research Center , Northwestern University , Hybrid Nanotechnology Experimental Resource ,

New 'Swiss Army Knife' Cleans Up Water Pollution

First used to soak up oil in water, new sponge sequesters excess phosphate from water
Phosphate Elimination and Recovery Lightweight (PEARL) membrane, a porous nanocomposite substrate, selectively sequesters up to 99% of phosphate ions from polluted water
Tunable membrane will address other environmental challenges through incorporation of specific nanomaterials
New tech meets need for sustainable, scalable and cost-effective solution that works outside the lab
Phosphate pollution in rivers, lakes and other waterways has reached dangerous levels, causing algae blooms that starve fish and aquatic plants of oxygen. Meanwhile, farmers worldwide are coming to terms with a dwindling reserve of phosphate fertilizers that feed half the world’s food supply. ....

Lake Erie , United States , Northwestern University , Great Lakes , Stephanie Ribet , Vikas Nandwana , Isaac Asimov , Julia Rosen , Benjamin Shindel , Vinayak Dravid , Northwestern International Institute Of Nanotechnology , Swiss Army , National Nanotechnology Coordinated Infrastructure , Northwestern University Atomic , National Science Foundation , Nanoscale Characterization Experimental Center , Northwestern Mccormick School Of Engineering , Proceedings Of The National Academy Science , Recovery Lightweight , Northwestern University Led , National Academy , Venn Diagram , Abraham Harris Professor , Materials Science , Mccormick School , Hybrid Nanotechnology Experimental Resource ,

New 'Swiss Army knife' cleans up water pollution

Phosphate Elimination and Recovery Lightweight (PEARL) membrane, a porous nanocomposite substrate, selectively sequesters up to 99% of phosphate ions from polluted water. Tunable membrane will address other environmental challenges through incorporation of specific nanomaterials. New tech meets need for sustainable, scalable and cost-effective solution that works outside the lab. ....

Lake Erie , United States , Northwestern University , Great Lakes , Stephanie Ribet , Vikas Nandwana , Isaac Asimov , Julia Rosen , Benjamin Shindel , Vinayak Dravid , Northwestern International Institute Of Nanotechnology , Swiss Army , National Nanotechnology Coordinated Infrastructure , Northwestern University Atomic , National Science Foundation , Nanoscale Characterization Experimental Center , Northwestern Mccormick School Of Engineering , Proceedings Of The National Academy Science , Northwestern University Led , National Academy , Venn Diagram , Abraham Harris Professor , Materials Science , Mccormick School , Hybrid Nanotechnology Experimental Resource , International Institute ,