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Genetic melting pot: Study unveils complex admixture in European ancestry populations

In a recent Nature Communications study, researchers revealed that Europeans and European Americans possess a significant subcontinental genetic admixture, challenging the notion that these populations are homogenous. This finding suggests the need to re-evaluate genetic epidemiology studies that may have overlooked the influence of admixture on disease associations and trait heritability in these groups. ....

United States , Hunter Shutterstock , Daniel Shriner , Global Health , Nature Communications , National Human Genome Research Institute , Research On Genomics , United States National Institutes Of Health , European Americans , Pixels Hunter , United States National Institutes , European American , Human Genome Diversity , Genome Diversity ,

Humans nearly wiped out a million years ago, Chinese study suggests

‘Bottleneck’ event revealed FitCoal model represents ‘milestone’ in the study of human evolution, co-author of paper published in latest issue of Science says. ....

United States , United Kingdom , City Of , Li Haipeng , Jin Xin , Nick Ashton , British Museum , Natural History Museum London , Research Institute , Shanghai Institute Of Nutrition , Shanghai East China Normal University , Shanghai Institute , East China Normal , Infinitesimal Time , Thousand Genomes Project , Human Genome Diversity , Nobel Prize , Thousand Genomes , Chris Stringer , Middle Pleistocene ,

Shocking Study: Human Ancestors Were on Brink of Extinction 1 Million Years Ago with Only 1,300 Survivors

Chinese study reveals a shocking human evolution revelation: a million years ago, a catastrophic bottleneck event reduced our ancestor population to just 1,300 individuals. ....

United Kingdom , United States , Janet Kelso , Nicholas Ashton , John Lopez , Pan Yi Hsuan , Jin Xin , British Museum , South China Morning Post , Max Planck Institute For Evolutionary Anthropology , Research Institute , Tech Times , Texas Heatwave Dries , Million Year Old Massive Dinosaur , Infinitesimal Time Coalescent , Thousand Genomes Project , Human Genome Diversity , Max Planck Institute , Evolutionary Anthropology ,

HMOX1 STR polymorphism and malaria: an analysis of a large clinical dataset | Malaria Journal

Inducible expression of heme oxygenase-1 (encoded by the gene HMOX1) may determine protection from heme released during malaria infections. A variable length, short tandem GT(n) repeat (STR) in HMOX1 that may influence gene expression has been associated with outcomes of human malaria in some studies. In this study, an analysis of the association between variation at the STR in HMOX1 on severe malaria and severe malaria subtypes is presented in a large, prospectively collected dataset (MalariaGEN). The HMOX1 STR was imputed using a recently developed reference haplotype panel designed for STRs. The STR was classified by total length and split into three alleles based on an observed trimodal distribution of repeat lengths. Logistic regression was used to assess the association between this repeat on cases of severe malaria and severe malaria subtypes (cerebral malaria and severe malarial anaemia). Individual analyses were performed for each MalariaGEN collection site and combined for me ....

Tom Williams , Professor Tom Williams , Wellcome Unit , Human Genome Diversity ,

Tracing the genetic history of humanity

Gathering genetic data has become easier and more cost effective over recent years. As a result, thousands of genomes have been generated both from modern humans and ancient ancestors. One of the major challenges for putting that information into a cohesive story is the variances in the way genome information is stored. ....

United States , Atlantic Ocean , Bryan Wong , Big Data Institute , University Of Oxford , Thousand Genomes Project , Simons Genome Diversity Project , Human Genome Diversity , North American ,